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The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9

High Lp(a) concentration may cause an artifactual increase in LDL-C concentration

For example, in diabetic retinopathy (DR), SIRT1 suppresses inflammation and retinal vascular damage by regulating HMGB1 deacetylation and inhibiting ferroptosis (Peng et al., 2025)

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