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Although rhGH-treatment partly restored reduced expression of GHR and IGF-1 in the kidneys and resulted in profound metabolic effects, including improved weight gain and lower urea serum levels, there was no difference with respect to renal recovery and mortality compared to placebo-treated controls

Planta 222:418427

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Consider intermittent fasting or caloric restriction, which may synergize with MOTS-cs AMPK-mediated effects

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