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Particularly, we found that mean plasma levels of Valine (U:140.9 mol/L, K:127.8 mol/L), Lysine (U:109.9 mol/L, K:95.7 mol/L), Threonine (U:67.5 mol/L, K:57.9 mol/L) and Tryptophan (U:2.9 mol/L, K:2.3 mol/L), fell below the expected ranges for healthy adolescents (UCSF Clinical Core Accepted Reference Ranges) for both those affected with konzo and their unaffected siblings

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Two forms of the disorder have been described: classic PKAN with symptom onset early in life (before age 10 years) and atypical PKAN with symptom onset after age 10, sometimes in early adulthood (19)

Clinical evidence suggests utility of fixed-dose combination of Dapagliflozin and Sitagliptin shown to be effective in uncontrolled T2DM or T2DM with multiple cardiovascular risk factors