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Restoring pharmacologic preconditioning in the aging heart: role of mitophagy/autophagy

Broad metabolic profiling established a primary role for CBP/p300 in NRF2-dependent accumulation of glutathione and glutathione-related metabolites

In a double-blind, randomized, placebo controlled trial, 38 runners [mean (SD) = 34 (7) yrs

It separates true treatment resistance from modifiable barriers such as dietary intake, physical activity, sleep quality, and stress, and argues these should be evaluated systematically before concluding the medication has failed

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Chronic inflammation and vascular damage, both common in metabolic syndrome, further contribute to cognitive decline