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Other studies have shown that GLP-1RA with melanocortin-4-receptor (MC4R) has a synergetic effect on body weight decrease [87,88]
Here, the GIP fragments GIP(15-42), GIP(15-30), GIP(16-30) and GIP(17-30) were characterized as weak antagonists at the human GIP receptor in vitro , and the amino acids number 6-30 are required for effective GIP receptor antagonism as a high-affinity binding domain (63) ( Figure 1 )
10.1016/j.celrep.2019.11.047 64 YuS.GuoX.YangH.SunY