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We found that APR-017 or LCS3 treatment induced an increased level of ROS and a decreased level of GSH (presented as the ratio of GSH to oxidized form, GSSG) in VRK2-KO cells, but not VRK2-WT cells (Fig

The 143B cells were cultured to 80% confluence, and incubated with 200 M hypoxyprobe and PBS, Ru(II)-OH, NP2, or NP4 (Ru 10 M) under hypoxia condition for 12 h