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On the contrary, NRF2 activators targeting KEAP1 thiols are recognized for their preventive potential for oxidative stress-related pathology such as Parkinsons disease, but have not proven effective for chronic patients largely due to their electrophilic high off-target nature [93]
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Canto E, Isobe N, Didonna A, Baranzini S, Bevan C, Bove R, et al
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A stable gastric pentadecapeptide that promotes angiogenesis through the VEGFR2 and nitric-oxide systems and supports soft-tissue healing in animal models
