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Similarly, comparable energy intake was found in CR and FR rats (CR rats = 340 4 kJ/day

To assess cost-effectiveness, a willingness-to-pay (WTP) threshold of three times the gross domestic product (GDP) per capita was used, which amounted to $36,528.3 per QALY gained in this study, following the recommendations of the World Health Organization (WHO) ( 2.6 Sensitivity analysis and price threshold analysis We performed a univariate sensitivity analysis to evaluate the impact of changing key inputs in the model, including the discount rate, initial utility, time horizon, costs, and disutility scores (Supplementary Table S5)

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