glp-1 nejm Receptor Agonists Why are GLP-1 agonists being

In summary, compounds 47 , 55 , 72 , and 74 resemble allopurinol and febuxostat, as they are multiorgan targets and hepatotoxic, whereas compounds 65 and 83 resemble topiroxostat, displaying a milder toxicity profile (see the Supporting Information: File S1)

Given the significant therapeutic value of this mechanism, we pursued a novel high-throughput screening strategy that identified a series of small-molecule GLP-1R agonist leads

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doi: 10.1210/jcem.86.3.7312 69 Hubalewska-DydejczykADuntasLGilis-JanuszewskaA

This cascade ultimately leads to ROS production and DNA damage, culminating in cardiomyocyte proliferation arrest and embryonic death [69]

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