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(15 September 2015) [1990]

Certain health conditions may require alternative approaches or represent contraindications completely

Poor sleep and chronic stress elevate cortisol levels, which can counteract appetite suppression and promote fat storage

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Studies tracking patients over 68 weeks show cumulative weight loss increases substantially as doses rise, with the greatest losses occurring between weeks 12 and 28

It also alters melanin production from eumelanin (dark pigment) to phaeomelanin (lighter pigment), which contributes to its skin-brightening effect.(2) This mechanism explains why its often promoted as a depigmenting agent for issues like melasma, sun spots, and post-inflammatory hyperpigmentation