By harnessing synergistic mechanismsincluding the metabolic flexibility of GIP, the glucagon-suppressing and appetite-suppressing effects of amylin, and the energy expenditure promoted by glucagonthese multi-agonists overcome the efficacy limitations of single-target therapies (44)
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Nouwen A et al (2010) Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis
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