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The inhibition of tumor cell migration and invasion by GLP1-RAs through regulating inflammatory factors and adhesion molecules, Matrix Metalloproteinase (MMP), and other molecules Preclinical studies have demonstrated that Ex-4 exhibits anti-tumor effects in human ovarian cancer cell lines SKOV-3 and CAOV-3 by activating the GLP-1R [78]

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Methods to stabilize the AR in an antagonist conformation should be explored for crystallizing the protein