Furthermore, SAE remains notably underdiagnosed and undertreated, and survivors often develop persistent long-term neurocognitive sequelae, including hippocampus-dependent memory impairment, psychiatric disorders and functional disability, which severely impact quality of life ( Oxidative stress is central to SAE pathogenesis, driven by an imbalance between excessive reactive oxygen species (ROS) production and impaired antioxidant defense systems (Yan et al., 2022)
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinsons disease and other synucleinopathies
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Jeong EM, Yoon J-H, Lim J, Shin J-W, Cho AY, Heo J, Lee KB, Lee J-H, Lee WJ, Kim H-J, Son YH, Lee S-J, Cho S-Y, Shin D-M, Choi K, Kim I-G
Shao X, Johnson JE, Richardson JA, Hiesberger T, Igarashi P