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Herkinorin, a MOR agonist, is unable to promote both phosphorylation and internalization indicating that the two processes could be linked (Groer et al., 2007)

None of the control participants had a history of serious medical or surgical illnesses, neurodevelopmental disorders, or substance abuse

However, this risk has not been demonstrated in humans at therapeutic doses, and the warning is being reevaluated based on post-marketing surveillance data

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