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PMID: 39067875 | doi:10.1136/jitc-2024-009281 Cant C et al

Osteoarthritis Cartilage 23 , 244248 (2015)

The absorbance for each condition was measured, and the percentage of cross-reactivity was calculated using the following equation, adapted for non-competitive sandwich immunoassays 53 : Cross-reactivity (%) = [(OD of cross-reactant analyte)/(OD of target analyte)] 100

Due to this interaction lactic acidemia impairs urate reabsorption and excretion while hyperuricemia results in impaired lactate excretion and reabsorption

The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity), completed in 2023 with over 17,600 participants, demonstrated a 20% reduction in major adverse cardiovascular events in patients with established cardiovascular disease and overweight or obesity but without diabetes

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