In fact, in a meta-analysis of 4 large studies (EMPA-REG, CANVAS, CREDENCE, and DECLARE-TIMI 58) a decrease in acute kidney injury was observed (Risk ratio 0.75
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Deletion of the key catalytic enzyme methylthioadenosine phosphorylase (MTAP) gene is associated with the sensitivity of GSK3368715, 331 and a current phase II clinical study of GSK3368715 in breast cancer has been enrolled (NCT04676516) (Table 1)