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We typically recommend weekly injections for the first month, and then monthly maintenance injections after that

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PMID: 32742317 15

The investigators attributed the angiogenic effect to upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) and activation of the Aktendothelial nitric oxide synthase (eNOS) signaling pathway

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However, evaluations of mutants, elite lines, and diverse germplasm repeatedly demonstrated substantial variability and occasional instability of reactions across seasons, reinforcing the need for robust, multi-year testing (Akhtar et al