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doi: 10.1073/pnas.1005198107 237 VergauwenB.PauwelsF.Van BeeumenJ

Why IGF-1 LR3 is more potent than native IGF-1 Native IGF-1 is largely sequestered in circulation by IGF binding proteins (IGFBPs) a family of six proteins that escort IGF-1 around the body and limit how much is free to engage receptors

Because topical research uses concentration-based dosing rather than absolute-mass dosing, the researcher must formulate the peptide into a carrier base at a target concentration, then apply a consistent volume to the research area