Rosenstock J, Fonseca VA, Gross JL, et al
Since the majority of testosterone release occurs during Slow-Wave Sleep (SWS), DSIPs dual action of enhancing SWS and directly stimulating LHRH creates a synergistic environment for hormonal recovery.11 Puberty and Development: The finding that DSIP levels and LH release both increase during sleep in puberty suggests the peptide may play a natural physiological role in the developmental surge of reproductive hormones.23 Cytoprotection, Anti-Aging, and Pain Management 7.1 Antioxidant and Mitochondrial Effects Beyond the brain, DSIP exhibits systemic cytoprotective properties
Genetics play an important role in determining HDL levels, but it isn't everything
Vd is ~0.5 L/kg (extracellular volume)
Wei Q, Li L, Chen JA, Wang SH, Sun ZL
As a result, their effects are not necessarily reflected by generating highest hormone concentrations in the bloodstream