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4% (placebo) due to adverse events Clinical Significance: This pivotal Phase 2 study established cagrilintide as an effective monotherapy for obesity, producing weight loss competitive with GLP-1 agonists but through a distinct mechanism
Journal of Agricultural and Food Chemistry, 70 (29), 9007-9016
It is important to note that this concern is entirely theoretical -- no oncological adverse effects have been reported in the limited preclinical studies -- but the biological plausibility is high enough to warrant serious consideration