When Madeson shared his data with Knudsen in 1995, she realised that it rang a bell because she had noticed that both normal and obese rates experienced a lasting and reversible weight loss when given one of her early GLP-1 analogues
Theyre the same molecules your biologic is designed to block
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Primary endpoints covered percent change in body weight and change in WOMAC pain score
Thus, it was widely prescribed
GLP-1 has revolutionized diabetes and obesity treatment, while GLP-2 offers hope for those with serious intestinal disorders
