demonstrated that GLP-1 treatment decreased phosphorylation of extracellular signal-regulated kinases ERK1/2 and additionally reversed downregulation of epigenetic factor histone deacetylase 6, a downstream molecular of the EKR1/2 whereby significantly reduced intracellular reactive oxygen species [128]
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The process of generating ATP naturally produces reactive oxygen species (ROS), which are highly volatile molecules that can cause severe cellular damage if left unchecked
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