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Clin Exp Pharmacol Physiol (2008) 35(12):14339.10.1111/j.1440-1681.2008.05015.x 24 MorrisonMEVijayasaradhiSEngelsteinDAlbinoAPHoughtonAN

Specifically, it upregulates genes involved in collagen synthesis (Types I, III, and V), decorin production (which regulates collagen fibril assembly), integrin and glycosaminoglycan synthesis, DNA repair enzymes, antioxidant defense systems (superoxide dismutase, glutathione), and stem cell markers

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Plasma levels of pro- and anti-inflammatory cytokines were increased in wild-type (WT) but not in TLR4-deficient (Tlr4/) mice, while GLP-1 secretion could be abolished when STC-1 cells were exposed to LPS in the presence of a TLR4 antagonist (TAK-242)