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Lancet 400(10366):18691881 Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S et al (2023) Retatrutide phase 2 obesity trial investigators

86 A combination of SAMe and silybin (Denamarin) was used in one study as a liver protectant in dogs receiving chemotherapy

The messaging appeals to a cultural affinity for phytotherapy and natural medicine but wraps it in the clothing of official pharmaceutical oversight

Lancet 402 , 693704 (2023)

This double-blind, randomized, placebo-controlled trial examined the effects of 2-HOBA on oxidative stress in both younger and older healthy adults

Notably, all patients had previously been treated with pentosan polysulfate, which is currently the only FDA approved treatment for interstitial cystitis, and had not responded