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doi: 10.21037/atm-21-6081 25 van TienhovenXAde Chvez GascnJRCano-HerreraGNehmeJASSouroujonTGonzalezMFBet al

Phase advancement, amplitude reduction, or decreased stability of the prolactin circadian rhythm (e.g., the prolactin peak occurring earlier than the cortisol peak) may promote fat accumulation and metabolic abnormalities (75)

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Typically, CEPS employs Cam esters as acyl donors and catalyzes the condensation of C-terminal peptide esters with N-terminal peptide fragments in aqueous conditions

however, the specific mechanism remains unclear