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Further increases to 1 mg may occur after at least 4 weeks, and to 2 mg after at least another 4 weeks if additional glycaemic control is needed

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The low molecular weight peptides (~10 kDa) can cross the blood-brain barrier, theoretically delivering neurotrophic support directly to neurons

True pathological hypercortisolism (Cushing's syndrome) is typically caused by endogenous ACTH excess, adrenal disease, or exogenous glucocorticoid medication use , rather than by chronic psychological stress alone

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