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When administered, semaglutide binds to GLP-1 receptors in the pancreas, stimulating insulin secretion in a glucose-dependent mannermeaning it only triggers insulin release when blood glucose levels are elevated

Kingham TP, Panageas KS, Ariyan CE, Busam KJ, Brady MS, Coit DG

This study demonstrates that the AOM model of HE generates a significant disruption of the BBB as measured by the presence of Evans blue dye in the cerebral cortices of AOM-treated mice

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What the studies are showing Here's where we need to pay attention to the emerging data