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Additionally, GIP may stimulate bone formation, indicating a possible separation between the processes of bone resorption and formation [47]

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Structural modifications such as cyclization, salt exchange, and sequence truncation are being explored to improve stability and absorption, particularly for oral administration models

In mice, HCD elevated plasma cholesterol and significantly improved survival (52.5% to 90%), independent of immune modulation.Hepatic transcriptomics revealed metabolic reprogramming, including upregulation of oxidative phosphorylation and glutathione-mediated antioxidant pathways, and suppression of endoplasmic reticulum proteostasis

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10.1016/j.metabol.2022.155383 Metabolism 300 ZhouH.RenJ.ToanS.MuiD