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New England Journal of Medicine 2023;389:2221-32

Mei J, Sun J, Wu J, Zheng X

This is suggestive of potential and likely transient interactions between acidic Glu1273 and the sequentially nearest (i-4) basic residue Lys1269

Why Semaglutide Causes Side Effects: The Mechanism Behind Discomfort Semaglutide activates GLP-1 receptors throughout your gastrointestinal tract and brain, triggering three primary effects: delayed gastric emptying, reduced appetite signaling, and slowed intestinal motility