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In the CY 2023 OPPS/ASC final rule with comment period (87 FR 71894 through 71895), we updated the device descriptor for C1831, effective January 1, 2023, to include the posterior/transforaminal approach at the request of the applicant

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By engaging all three pathways, researchers aim to observe more comprehensive metabolic regulation than is possible with single-receptor agonists

52,53 In a phase 2, multi-center trial conducted at 45 centers, orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide