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Long-term safety is being studied in ongoing trials

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For instance, the American Diabetes Association only recommends the use of GLP-1 drugs for weight loss for those with a body mass index, or BMI, of at least 30, or among those with a BMI of 27 or greater if they have at least one other condition such as type 2 diabetes, hypertension or high cholesterol

For individuals with diabetes, the ketogenic diet in combination with GLP-1 therapy could increase the risk of diabetic ketoacidosis and hypoglycemia