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These included gallbladder cancer (HR = 0.35), meningioma (HR = 0.37), pancreatic cancer (HR = 0.41), hepatocellular carcinoma (HR = 0.47), ovarian cancer (HR = 0.52), colorectal cancer (HR = 0.54), multiple myeloma (HR = 0.59), esophageal cancer (HR = 0.60), endometrial cancer (HR = 0.74), and kidney cancer (HR = 0.76)

This appears to involve a particular enzyme complex called mitochondrial complex I

In some malignancies, including glioma, breast, ovarian, colon, and osteocarcinoma, melatonin can target cancer stem cells (CSCs) as a tumor suppressor

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Standard Berberine HCI is also included for maximum effectiveness