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Factors like age, metabolism, diet, lifestyle, and genetics can influence the results of longevity

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Risk-of-bias reduction strategies such as robust randomization methods, allocation concealment, blinding of outcome assessors, and intention-to-treat analysis should be incorporated to improve internal validity and reproducibility

Furthermore, the management of oxidative stress and neuroinflammation is a critical aspect of treating neurodegenerative processes, as seen in AD models where flavonoid compounds exhibit neuroprotective effects by modulating antioxidant pathways (Xu et al., 2023)