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Among the compounds that the enzyme reduces there are phospholipids, fatty acids and DNA hydroperoxides produced by lipid peroxidation and oxidative damage to DNA 1
Binding to and phosphorylation of Sab by p-JNK leads to inactivation of p-Src on the inner mitochondrial membrane, which then inhibits electron transport and increases reactive oxygen species release [54,60], thus amplifying oxidant stress and peroxynitrite formation [42]
It should be noted that eryptotic RBCs are cleared from the circulation in an efferocytosis-dependent fashion within minutes, in contrast to senescent erythrocytes [77], which require days to be engulfed by macrophages and cleared [72]
J Clin Invest
(Source) Healthy Skin needs a healthy Gut
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