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(4) An increased prevalence of depression is documented among patients with pediatric TT [336], especially in adolescents, who often need psychological support, due to the difficulty in expressing discomfort or addressing concerns with both family members and doctors [337]

The Montreal cohort is supported by grants from the National Institutes of Health (NIH) U19AI159819 and the Canadian Institutes of Health Research (CIHR) (PJT-173467) to N.S

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In contrast, peptides whose human effects remain weak or inconsistent despite adequate exposure may warrant lower priority absent new mechanistic insights

Figure 1 presents the main effects of GLP1, GIP and glucagon in different body organs