Hence, the dedifferentiated phenotype observed in FN-exposed MCs could reflect one of several steps that are required during early stages of melanoma initiation
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among those, stronger evidence exists for metabolic disorders, allergies, autoimmune diseases, disturbances of the central nervous system, and some forms of cancer (Fitzgibbon and Mills 2020)
In the past, this was difficult because glutathione is easily destroyed in the gut