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80 Multiple-ascending-dose and short-term studies in patients with NASH or dyslipidemia showed that pegozafermin substantially reduced triglycerides, increased HDL cholesterol, and lowered hepatic fat content, with good tolerability and low immunogenicity

The results of liver histopathology and liver serum biochemistry examined in NAFLD mice show that GA administration prevents hepatic adipose deformation, insulin resistance, and hypercholesterolemia induced by HFD

doi: 10.1134/S1021443707020021 213 TehranifarA.AmeriA

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Another possible downside is cost