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Notably, affective blunting has been reported as a side effect of other commonly prescribed medications, including SSRIs and beta blockers (MacCormack et al., 2021

The pharmacokinetics of tirzepatide after a single 5 mg dose was evaluated in patients with different degrees of hepatic impairment (mild, moderate, severe) compared with subjects with normal hepatic function [see Use in Specific Populations (8.7)]

Cell Discov 10, 77 (2024)

Tirzepatide supports blood sugar control, appetite regulation, reduced food intake, and overall metabolic function

The oral formulation almost certainly delivers less bioavailable peptide than equivalent injectable doses, but the delivered amount may still cross therapeutic thresholds for some individuals and conditions