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Famotidine for PMDD: Famotidine is commonly used as a heartburn medication, but it may also block histamine receptors and reduce inflammation and mood disturbances due to its effects on the nervous system 7

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However, another study using the CLP mouse model found that administering choline before and after sepsis initiation reduced serum inflammatory mediators such as TNF- and HMGB1, and improved survival via the 7nAChR-dependent mechanism (250, 251)