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Health conditions Sometimes the diet is fine, but an underlying condition gets in the way

Nevertheless, an immunologically cold and immune-suppressive TME associated with prostate cancer (PCa) has limited the effectiveness of ICIs [165]

Song et al., 2025

In addition, ectopic expression of POU2F3 with COLCA2 in HEK293T cells activated the expression of AVIL, a POU2F3 direct target

Taking too little may bring no noticeable results, while taking too much could cause mild side effects

However, limitations exist in the form of in vivo instability, the reliance on carriers that are biocompatible and robust and limited sites of application (local and direct) (Park et al