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Exclusion criteria observed in Phase 2 trials included individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, given the class-level concern with GLP-1 receptor agonists and C-cell tumours in rodent models [8]

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Key findings from the trial (Jastreboff et al., NEJM 2023) included: Placebo group : Mean body weight reduction of approximately 2.1% from baseline at 48 weeks