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Mental stress should be addressed among individuals with obesity, as chronic stress may promote obesity development through the sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation that elevates cortisol levels, interferes with insulin sensitivity, promotes energy storage, and creates food cravings for ultra-processed comfort foods [180] GLP-1s may act both centrally and peripherally to reduce these downstream impacts of chronic stress and obesity and alter food reward pathways in positive ways [124]

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GLP-1 receptors are found in the heart and blood vessels, influencing blood pressure, lipid profiles and inflammation

Conclusion Innovative business models that improve GLP-1 adherence have the potential to grow into the next generation of diet and nutrition giants, enhancing health and nutrition outcomes for millions of Americans

Bethel MA, Patel RA, Merrill P, et al