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San Juan I, Bruzzone C, Bizkarguenaga M et al (2020) Abnormal concentration of porphyrins in serum from COVID-19 patients

[5] [6] The STEP trials evaluating semaglutide for weight management showed similar patterns, with gastrointestinal adverse events being the primary reason for treatment discontinuation in a small percentage of participants

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Potential benefits of split dosing include reduced GI side effects (lower peak concentration), more consistent appetite suppression throughout the week, and better tolerance at higher doses