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2022 AHA/ACC/HFSA guideline for the management of heart failure: Executive summary: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, Journal of the American College of Cardiology (2022) Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk, Lancet Regional Health Europe (2024) Farxiga drug label, NIH DailyMed (2024) Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidencebased practice, Experimental and Therapeutic Medicine (2024) Dapagliflozin monotherapy in Type 2 diabetic patients with inadequate glycemic control by diet and exercise, Diabetes Care (2010) Aetna 2025 Standard Plan, Aetna (2025) Humana 2025 Medicare Advantage Plan, Humana (2025) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

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Figure 2 Muscle signaling molecules Wallace et al

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