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doi: 10.3389/fimmu.2025.1536569 Received 29 November 2024 Accepted 27 January 2025 Published 17 February 2025 Volume 16 - 2025 Edited by Stergios Boussios, Canterbury Christ Church University, United Kingdom Reviewed by Xiaohong Tan, Bowling Green State University, United States Lai Jiang, Zhejiang Chinese Medical University, China Updates Copyright 2025 Mathavan, Tam, Mustaffa and Tye

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Reproduction 155:R199-209 Quaile MP, Melich DH, Jordan HL, Nold JB, Chism JP, Polli JW (2010) Toxicity and toxicokinetics of metformin in rats

Damaged mtDNA can further debilitate mitochondrial functionality, promoting the generation of ROS and establishing a cycle of increasing mitochondrial malfunction and oxidative stress [135]

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Aber auch wenn das Arzneimittel in einer nicht zugelassenen Indikation (Off-Label-Use) oder einer abweichenden Dosierung oder einem abweichenden Applikationsweg angewendet wird sowie bei Missbrauch und Medikationsfehlern, knnen UAW auftreten