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The stimulative laxatives should be kept in reserve for acute episodes of constipation

Other notable adverse effects include: Injection site reactions : Mild erythema, itching, or swelling at the subcutaneous injection site Hypoglycaemia : Particularly when tirzepatide is used in combination with insulin or sulphonylureas

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Assessment of trimethylamine N-oxide TMAO concentration did not show significant differences for RA disease activity (Supplementary Table S2), prednisolone medication (Supplementary Table S3), periodontal diagnosis (Supplementary Table S4), CAL (Supplementary Table S5) or smoking (Supplementary Table S6)

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