Actions of VIP in the body include: Vasodilation to assist in blood pressure regulation, GI tract epithelial cell secretion and blood flow increasing water and electrolytes in the GI tract, relaxation of intestinal smooth muscle, exerting a positive effect on hypothalamic kisspeptin neurons, hormone balancing, and aromatase inhibiting effect corrects estradiol, 25-OH Vitamin D, and testosterone in males, downregulation of th1 responses and controlling cytokine responses to restore immunoregulation, especially following infections by intracellular bacteria and viruses
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Proteomic analyses revealed that NNMT inhibition uniquely upregulated proteins involved in translation initiation, ribosomal biogenesis, and inflammatory regulation during muscle regeneration, suggesting multiple complementary mechanisms supporting muscle function
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