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If there is any doubt about the integrity of a solution whether due to appearance, storage history, or uncertainty about the beyond-use date the safest course of action is always to discard it and seek advice from the trial team, supervising clinician, or a registered pharmacist before proceeding

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However, folate supplementation can mask these haematological changes whilst neurological damage continues, highlighting the importance of checking B12 status before commencing folate therapy

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