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Consider the case of megaloblastic anemia where vitamin B deficiency causes the production of unusually big and inefficient red blood cells

Dispose of the needle safely

Pizzuti D, Bortolami M, Mazzon E et al (2004) Transcriptional downregulation of tight junction protein ZO-1 in active coeliac disease is reversed after a gluten-free diet

The needle should enter the joint without significant resistance

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