What made exendin-4 particularly interesting was its resistance to degradation in the body and its longer-lasting effects compared to native human GLP-1
In 2012, our group reported a novel (4 + 3) strategy for preparing cyclohepta[ b ]indoles in a single chemical transformation by means of a three-component annulation reaction beginning with an indole, a carbonyl, and a diene 2
What if you left GLP-1 out for too long
Recognition of this has spurred a number of innovative approaches that, despite their preclinical promise, have yielded disappointing efforts at translation into a meaningful clinical role
Moreover, we retrieved other relevant records 56,57,58 : two large ( N = 133,318 and N = 342,608, respectively) cohort studies in people with diabetes across 613 years noted a beneficial association between GLP-1RA prescriptions compared with non-prescription and lower diagnoses of dementia 57,58 , while a small ( N = 154 patients with T2DM) and shorter (~12 months) cross-sectional investigation of GLP-1RAs in addition to metformin, compared with metformin alone, observed better MoCA scores in the former group 56
According to IQVIA, this creates an unusually short branded exclusivity window: generic manufacturers are positioned to flood the market with lower-cost alternatives, potentially extending GLP-1 treatment to a far broader patient population
